Zosyn piperacillin and tazobactam for injection, usp the. Oct, 2019 antibiotik meropenem pdf carbapenems eg, imipenem, meropenem and the monobactam antibiotic aztreonam are generally reserved for serious infections caused by. To prevent sloughing and necrosis in areas in which extravasation has taken place, the area should be infiltrated as soon as possible with 10 ml to 15 ml of saline solution containing from 5 mg to 10 mg of regitine brand of phentolamine, an adrenergic blocking agent. Ceftazidimeavibactam and meropenem vaborbactam are changing the management of invasive infections due to carbapenemresistant enterobacteriaceae cre, leading to higher rates of clinical cure, decreased mortality, and decreased rates of acute kidney injury compared with colistinbased regimens.
Iv meropenem for injection, for intravenous use initial u. For intravenous use only 500 mg per vial 10 x 500 mg sterile vials 7012114537 meropenem for injection, usp i. En1544 page 3 of 5 important antidote for extravasation ischemia. In clinical trials, one class iii patients death was judged attributable to the interruption of flolan. These authors concluded that because females most at risk for oc failure or noncompliance packagge not be easily identified and the true incidence of such events may be underreported, ertalenem given the serious consequence of unwanted pregnancy, that. While the vial of meropenem is sitting on a flat surface, insert the needle through the rubber stopper into the vial.
Generally, carbapenems are well tolerated with a low risk for allergic reactions. Highlights of prescribing information these highlights do not include all the information needed to use zemdri safely and effectively. Meropenem for injection, usp is supplied in 20 ml and 30 ml injection vials containing sufficient meropenem to deliver 500 mg or 1 gram for intravenous administration, respectively. Dec 11, 2019 meropenem for injection, usp is supplied in 20 ml and 30 ml injection vials containing sufficient meropenem to deliver 500 mg or 1 gram for intravenous administration, respectively. Package label principal display meropenem 500 mg single dose vial label ndc 6332350720 meropenem for injection, usp i. Pdf meropenem is a new carbapenem antibacterial agent with wide spectrum of activity against gramnegative, grampositive and anaerobic organisms. Information for the user meropenem 500 mg and 1 g powder for solution for injectioninfusion read all of this leaflet carefully before you start using this medicine because it contains important information for you. Meropenem per vial ill ill 4524001 din 02415224 sans latex free meropenem for injection, usp per vial sterilesterile for intravenous use antibiotic sinale use vial. Highlights of prescribing information see full prescribing. In patients with changing renal function, serum creatinine. The osmolality of the reconstituted solution of meropenem for injection usp and sodium chloride injection usp is approximately 356 mosmolkg for the 500 mg dose. Nephrotoxicity, ototoxicity, neuromuscular blockade and fetal harm.
Meropenem and its metabolite are readily dialyzable and effectively removed by hemodialysis. Zosyn piperacillin and tazobactam for injection, usp is an injectable antibacterial combination product consisting of the semisynthetic antibiotic piperacillin sodium and the. Indications and usage merrem iv is a penem antibacterial indicated for the treatment of. Diminished renal function and central nervous system lesions may increase the risk of seizures. Dailymed meropenem meropenem injection, powder, for solution. Information for the user meropenem 500 mg and 1 g powder for solution for injectioninfusion read all of this leaflet carefully before you start using this medicine because it. Dailymed meropenem injection, powder, for solution. Meropenem fda prescribing information, side effects and uses.
Escherichia coli, klebsiella pneumoniae, and enterobacter cloacae species complex. Vabomere meropenem and vaborbactam is indicated for the treatment of patients 18 years of age and older with complicated urinary tract infections cuti including pyelonephritis caused by the following susceptible microorganisms. The recommended dose of meropenem for injection, usp i. Manufacturer states data insufficient to make dosage recommendations in patients undergoing hemodialysis or peritoneal dialysis. Flolan is a potent pulmonary and systemic vasodilator and can cause hypotension and other. Nov 17, 2019 package label principal display meropenem 500 mg single dose vial label ndc 6332350720 meropenem for injection, usp i. Ceftazidimeavibactam, meropenemvaborbactam, or both. Lidocaine is the diluent for im administration of ertapenem. Pelvic inflammatory disease caused by staphylococcus epidermidis methicillinsusceptible. Meropenem for injection product monograph page 4 of 39 gynecologic gynecologic infections caused by staphylococcus aureus methicillinsusceptible strains only, staphylococcus epidermidis methicillinsusceptible strains only, escherichia coli, prevotella bivia, and peptostreptococcus species. Meropenem for injection, usp is a sterile, pyrogenfree, synthetic, carbapenem antibacterial for intravenous administration. Vabomere meropenem and vaborbactam for injection, for intravenous use.
Merrem iv meropenem for injection, for intravenous use. Minimum inhibitory concentrations mcgml disk diffusion zone diameter in mm pathogen. For intravenous use only 1 g per vial 10 x 1 g sterile vials visit for full prescribing information. Indications and usage, intraabdominal infections, pediatric patients less than 3 months of age 1. Zemdri plazomicin injection, for intravenous use initial u. Add 20 ml sterile water for injection which provides 20 ml package insert. Jul 24, 2019 however, the elimination halflife of ertapenem is increased only from 4 to 4. The concomitant use of valproic acidsodium valproate and meropenem for injection is not recommended see drug interactions.
Each 500 mg meropenem for injection in the duplex container will deliver 500 mg of meropenem and a total sodium content of 245. In clinical trials, one class iii patients death was judged. The reported incidence of rash, pruritus, and urticaria was 0. Complicated skin and skin structure infections adult patients and pediatric patients 3 months of age and older only. Description cefoxitin for injection is a semisynthetic, broadspectrum cepha antibiotic sealed under nitrogen for intravenous administration. Levophed norepinephrine bitartrate injection, usp rx. Invanz ertapenemfor injection for intravenous iv or intramuscular im use initial u. To reduce the development of drugresistant bacteria and maintain the effectiveness of.
Easy to read fda package insert, drug facts, dosage and administration, and adverse effects for merrem meropenem. Push the plunger of the syringe, and insert all of the sterile water into the vial of meropenem. Application product type product name product description product number. Vabomere meropenem and vaborbactam for injection, for intravenous use initial u.
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